AB-452673-3 OUTCOMES OF FUNCTIONAL SUBSTRATE MAPPING OF VENTRICULAR TACHYCARDIA (FUNC-VT) - AN INTERNATIONAL MATCHED PROSPECTIVE REGISTRY

Dynamic substrate changes play a key role in facilitating conduction delay and re-entry ventricular tachycardia (VT) circuits. Extrastimuli pacing can unmask functional channels demonstrated by dynamic delay, which may the VT circuit. We have previously developed sense protocol mapping, using short coupled single extrastimuli to delineate areas of maladaptive an essential part development. This multicentre prospective propensity-matched registry mapping (Func-VT registry) aims compare procedural follow-up outcomes with conventional ablation. Procedure times, mortality, probability ATP/ICD shocks were compared matched institutional cohort. conducted international 44 patients ischemic heart disease undergoing through extra stimuli invoke decremental signal (Sense Protocol). Areas targeted for ablation conjunction pacemapping or entrainment where appropriate. data was against cohort guided entrainment, only The age, gender left ejection fraction. There (mean age 70 ±10.64 years, 95% males, mean fraction (EF) 33%) Func-VT 49 72 ±9.42years, 90% EF 29%). median procedure time 178min 185min (p=<0.005). Post ablation, there ATP reduction 13.74 ±4.53 (p=0.002) shock 4.078 ±5.74 (p=0.01) as 12-month all-cause mortality rate 4.5% vs 20.4% (OR 1.46, p=0.04). study shows that targeting signals Sense addition methods improved terms device therapy reduced when previous methods.